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CYP2E1 and Oxidative Liver Injury by Alcohol - PMC

For example, if a patient with Crohn’s disease is on an anti-TNF therapy and has had some improvement in their intestinal symptoms but still has active perianal fistulas or persistent inflammation on endoscopy, I may consider adding a second agent to target a different pathway.” “In contrast, if that same patient had no meaningful improvement at all despite adequate drug levels [in the blood], I would be more likely to switch to a different class of therapy rather than stack," Ali says

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Stop use and seek emergency care if you have hives, swelling of face/lips/tongue/throat, or trouble breathing